Description

(3S)-8-Amino-9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a critical building block for the synthesis of novel fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. This compound is essential for research institutions and pharmaceutical manufacturers focused on antibiotic development, chemical synthesis, and advanced pharmaceutical production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of next-generation fluoroquinolone antibiotic active pharmaceutical ingredients (APIs).
• Antibiotic Research & Development: Serves as a core scaffold for medicinal chemists developing new antibacterial compounds with improved efficacy and spectrum.
• Chemical Synthesis: Used in complex organic synthesis for constructing the pyridobenzoxazine carboxylic acid core structure.
• Bulk Drug Substance Manufacturing: Employed in cGMP-compliant production processes for target antibiotic APIs.
• Analytical Reference Standard: Utilized as a high-purity standard for quality control and analytical method development in pharmaceutical labs.
• Process Chemistry: Integral to scale-up and optimization studies for efficient industrial-scale antibiotic production.

Basic Information

Item	Detail
Product Name	(3S)-8-Amino-9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid
CAS No.	135325-15-4
Molecular Formula	C₁₅H₁₂F₂N₂O₄
Molecular Weight	322.27 g/mol
Synonyms	(3S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-8-amino-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (S)-Ofloxacin Intermediate; Ofloxacin Impurity; (S)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid 8-amine; Levofloxacin Related Compound; Fluoroquinolone Intermediate B; (3S)-8-Amino-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our (3S)-8-Amino-9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.