Description

Ac-Cys(Farnesyl)-Ome is a specialized, high-purity peptide derivative featuring a farnesyl thioether modification on a cysteine residue, with N-terminal acetylation and C-terminal methyl ester protection. This compound serves as a critical biochemical tool and synthetic intermediate for studying protein prenylation, a key post-translational modification involved in cellular signaling and membrane association. It is primarily utilized by researchers and manufacturers in pharmaceutical development, biotechnology, and academic research for investigating cancer pathways, neurodegenerative diseases, and developing targeted therapeutics.

Application

• Biochemical Research: Used as a reference standard or substrate in enzymatic assays to study farnesyltransferase activity and inhibition.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of prenylated peptide-based drug candidates and probes.
• Proteomics & Signal Transduction Studies: Employed to mimic or inhibit the natural farnesylation of proteins like Ras, Rho, and nuclear lamins to elucidate their function.
• Cell Biology Tools: Utilized for cell-permeable peptide synthesis to modulate protein localization and function within living cells.
• Diagnostic Development: Acts as a critical component in developing assays for detecting abnormalities in protein prenylation pathways linked to diseases.

Basic Information

Product Name	Ac-Cys(Farnesyl)-Ome
CAS No.	135304-08-4
Molecular Formula	C24H40N2O3S
Molecular Weight	436.65 g/mol
Synonyms	N-Acetyl-S-[(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine methyl ester; Acetylcysteine farnesyl methyl ester; N-Acetyl-S-farnesyl-L-cysteine methyl ester; S-Farnesyl-N-acetylcysteine methyl ester; Farnesylthioacetylcysteine methyl ester; L-Cysteine, N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-, methyl ester; Prenylated cysteine derivative
EINECS	Contact for details

Quality Control

Our Ac-Cys(Farnesyl)-Ome is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.