Description

Nle-Antiflammin-2 is a synthetic peptide analog of the natural anti-inflammatory protein lipocortin-1, designed for research and development applications. This compound is valued for its potent anti-inflammatory and anti-chemotactic properties, making it a critical tool for studying cellular signaling pathways and inflammatory responses. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, dermatology, and novel therapeutic discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of inflammation, immune cell migration (chemotaxis), and signal transduction mechanisms.
• Pharmaceutical Development: Serves as a lead compound or molecular probe in the discovery and validation of new anti-inflammatory drugs and biologics.
• In Vitro Diagnostics: Employed in assay development for screening inflammatory biomarkers and evaluating drug efficacy in cell-based models.
• Academic Studies: Facilitates fundamental research in biochemistry, molecular biology, and immunology to understand protein-protein interactions and regulatory processes.
• Dermatological Research: Investigated for potential applications in models of skin inflammation and related disorders.

Basic Information

Product Name	Nle-Antiflammin-2
CAS No.	135261-87-9
Molecular Formula	C58H94N16O16
Molecular Weight	1247.5 g/mol
Synonyms	Nle-Antiflammin 2; Norleucine-Antiflammin-2; AF-2 Peptide; Antiflammin-2 Analog; H-MDQVNFGLFK-NH2 (Nle1); Lipocortin-1-derived peptide analog; Anti-inflammatory peptide 2; Nle-AF-2
EINECS	Contact for details

Quality Control

Our Nle-Antiflammin-2 is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for peptide synthesis, and our quality system supports compliance with relevant global standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the vial under an inert atmosphere or desiccated after opening. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.