Description

α-Conotoxin Sia CAS NO 135190-31-7 is a highly selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound matters as a critical research tool for studying and characterizing specific subtypes of nicotinic acetylcholine receptors (nAChRs) in the nervous system. Researchers in neuroscience and pharmacology need it for investigating receptor function, developing novel therapeutic targets for neurological disorders, and as a standard in biochemical assays.

Application

• Neuroscience Research: Selective probing and inhibition of α3β2 and α3β4 nicotinic acetylcholine receptor subtypes.
• Pharmacological Studies: Investigation of receptor-ligand interactions, signal transduction pathways, and synaptic transmission.
• Drug Discovery: Serving as a molecular template or lead compound for developing new analgesics or treatments for neuropathic pain.
• Biochemical Assays: Use as a reference standard in competitive binding assays and functional studies.
• Toxicology Research: Studying the mechanisms of neurotoxins and their physiological effects.
• Academic & Institutional R&D: Fundamental research in universities and institutes focused on neurobiology and ion channel function.

Basic Information

Product Name	α-Conotoxin Sia
CAS No.	135190-31-7
Molecular Formula	C58H86N20O18S4
Molecular Weight	1399.66 g/mol
Synonyms	α-Conotoxin SIA; Conotoxin SIA; α-Conotoxin SIA; SIA Conotoxin; α-SIA; Alpha Conotoxin Sia; Nicotinic Acetylcholine Receptor Antagonist SIA; [Arg9, Lys12, Asn14]-α-Conotoxin SI
EINECS	Contact for details

Quality Control

Our α-Conotoxin Sia is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing including HPLC for purity verification, mass spectrometry for identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified per batch (nM range)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.