Description

n-Fmoc-L-Norvaline CAS NO 135112-28-6 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled elongation of peptide chains while preventing unwanted side reactions. It is primarily required by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the sequential assembly of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Acts as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Utilized in studying protein structure-function relationships and enzyme-substrate interactions.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering peptide synthesis services.

Basic Information

Product Name	n-Fmoc-L-Norvaline
CAS No.	135112-28-6
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-Nva-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norvaline; Fmoc-L-2-aminopentanoic acid; L-Norvaline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-α-Fmoc-L-norvaline; Fmoc-Norvaline-OH; N-Fluorenylmethoxycarbonyl-L-norvaline
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Norvaline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	Contact for details
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.