Description

Enkephalin, Pen(2,5)-4'-Iodo-Phe(4)- CAS NO 135108-10-0 is a synthetic, iodinated peptide analog of the endogenous opioid peptide enkephalin. This modified compound is of significant value in biochemical and pharmacological research due to its enhanced receptor binding affinity and stability, making it a crucial tool for studying opioid receptor subtypes and signal transduction pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, pain management research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a high-affinity ligand for probing delta (δ) and mu (μ) opioid receptor distribution, function, and internalization.
• Pharmacological Assays: Used in competitive binding studies and functional assays (e.g., GTPγS) to characterize new opioid compounds and assess receptor activation.
• Biomarker Development: Potential use in the development of radiolabeled (e.g., with I-125) tracers for in vitro and in vivo imaging studies.
• Structure-Activity Relationship (SAR) Studies: Serves as a key reference compound for designing and testing new peptide-based analgesics with modified pharmacological profiles.
• Cell Signaling Research: Investigation of G-protein coupled receptor (GPCR) mediated pathways involved in pain modulation and neuroprotection.
• Reference Standard: Used as a certified reference material in analytical laboratories for method development and quality control of related peptide substances.

Basic Information

Item	Detail
Product Name	Enkephalin, Pen(2,5)-4'-Iodo-Phe(4)-
CAS No.	135108-10-0
Molecular Formula	C34H46N6O8SI
Molecular Weight	785.74 g/mol
Synonyms	4'-Iodo-Phe(4)-Enkephalin, Pen; [Pen2,5, 4'-I-Phe4]Enkephalin; Iodinated D-Penicillamine(2,5)-Enkephalin; D-Pen2,5-4'-I-Phe4-Enkephalin; DPDPE analog; δ-opioid receptor selective ligand; Tyr-D-Pen-Gly-Phe(4-I)-D-Pen-OH; (2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3,3-dimethylbutanoic acid
EINECS	Contact for details

Quality Control

Our Enkephalin, Pen(2,5)-4'-Iodo-Phe(4)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation, mass spectrometry for molecular weight verification, and amino acid analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures material suitable for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.