Description

6-[(4-Methylphenyl)Thio]-2-Oxo-9-(2’,3’,5’-Tri-o-Acetyl--D-Ribofuranosyl)-2,3-Dihydropurine is a sophisticated nucleoside analogue derivative, primarily utilized as a key synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its role as a crucial building block for the synthesis of modified nucleosides and potential antiviral or anticancer agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer drug candidates.
• Biochemical Research: Used in academic and industrial research to study enzyme inhibition, nucleic acid chemistry, and the structure-activity relationships of modified purines.
• Antiviral Agent Development: Serves as a precursor in the development of compounds targeting viral polymerases and replication mechanisms.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating specialized libraries of compounds for high-throughput screening.
• Prodrug Synthesis: Utilized in the design and synthesis of prodrug forms of nucleoside analogues to improve bioavailability and pharmacokinetic profiles.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	6-[(4-Methylphenyl)Thio]-2-Oxo-9-(2’,3’,5’-Tri-o-Acetyl--D-Ribofuranosyl)-2,3-Dihydropurine
CAS No.	135041-24-6
Molecular Formula	C25H26N4O8S
Molecular Weight	542.56 g/mol
Synonyms	9-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-6-[(4-methylphenyl)thio]-9H-purin-2(3H)-one; 6-(p-Tolylthio)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purin-2-one; 6-[(4-Methylphenyl)thio]-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purin-2(3H)-one; Acetylated Thioguanosine Derivative; Modified Nucleoside Intermediate; 6-(4-Methylphenylthio)purine riboside triacetate
EINECS	Contact for details

Quality Control

Every batch of 6-[(4-Methylphenyl)Thio]-2-Oxo-9-(2’,3’,5’-Tri-o-Acetyl--D-Ribofuranosyl)-2,3-Dihydropurine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development use under current Good Manufacturing Practice (cGMP) principles where required. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, purity by HPLC, and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.