Description

D-Erythro-N,N,n-Trimethylsphingosine Chloride is a chemically modified sphingolipid derivative, specifically a trimethylated sphingosine salt. This compound is a critical intermediate and reference standard in lipid biochemistry and pharmaceutical research, enabling the study of sphingolipid metabolism and signaling pathways. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly those focused on oncology, neurology, and metabolic disease research, as well as in the development of high-purity active pharmaceutical ingredients (APIs).

Application

• Biochemical Research: A key reference standard and precursor for studying sphingolipid metabolism, cell signaling, apoptosis, and autophagy pathways.
• Pharmaceutical Development: Serves as a critical intermediate in the synthesis of novel therapeutic agents targeting cancer, neurodegenerative diseases, and inflammatory disorders.
• Enzyme Inhibition Studies: Used as a potent and specific inhibitor of sphingosine kinase (SphK) in mechanistic and pharmacological research.
• Cell Biology & Diagnostics: Employed in cell culture studies to modulate ceramide and sphingosine-1-phosphate levels, helping to elucidate their roles in disease models.
• Standards & Calibration: Provides a high-purity standard for analytical methods such as HPLC and LC-MS in quality control and metabolomics laboratories.

Basic Information

Product Name	D-Erythro-N,N,n-Trimethylsphingosine Chloride
CAS No.	134962-48-4
Molecular Formula	C21H44ClNO2
Molecular Weight	378.04 g/mol
Synonyms	D-erythro-N,N,N-Trimethylsphingosine Chloride; (2S,3R)-2-(Dimethylamino)-3-octadecanamido-1-propanol Chloride; FTY 720 Precursor; Fingolimod Intermediate; Sphingosine Kinase Inhibitor; N,N,N-Trimethyl-D-erythro-sphingosine Chloride; Sphingolipid Analogue; 2-[(2S,3R,4E)-3-Hydroxy-1-(dimethylamino)-4-octadecen-2-yl]propan-2-ol Chloride
EINECS	Contact for details

Quality Control

Our D-Erythro-N,N,n-Trimethylsphingosine Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure compliance with research-grade and potential GMP standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.