Description

Cbz-o-Methyl-L-Ser CAS NO 134807-65-1 is a protected derivative of the amino acid L-serine, featuring a carboxybenzyl (Cbz) protecting group on the amine and a methyl ether on the hydroxyl side chain. This compound is a crucial chiral building block and intermediate in the synthesis of complex peptides, peptidomimetics, and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified serine residues, influencing peptide stability and bioactivity.
• Medicinal Chemistry Research: Serves as a building block for creating focused libraries and structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in the scalable production of APIs where specific side-chain protection is required.
• Bioconjugation: Can be used to introduce functional handles or linkers into biomolecules for drug delivery or diagnostic applications.
• Academic Research: Utilized in university and institutional labs for studying enzyme mechanisms, protein engineering, and chemical biology.

Basic Information

Item	Details
Product Name	Cbz-o-Methyl-L-Ser
CAS No.	134807-65-1
Molecular Formula	C12H15NO5
Molecular Weight	253.25 g/mol
Synonyms	N-Carbobenzyloxy-O-methyl-L-serine; (S)-2-(((Benzyloxy)carbonyl)amino)-3-methoxypropanoic acid; Z-O-Me-L-Ser-OH; N-Cbz-O-methyl-L-serine; Cbz-Ser(OMe)-OH; Benzyl N-[(2S)-2-carboxy-1-methoxyethyl]carbamate; O-Methyl-N-carbobenzyloxy-L-serine
EINECS	Contact for details

Quality Control

Our Cbz-o-Methyl-L-Ser is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.