Description

4-Amino-6,7-dimethoxy-1H-quinazolin-2-one hydrochloride is a high-purity, pharmaceutically relevant quinazoline derivative, primarily utilized as a critical synthetic intermediate. Its value lies in its role as a key building block for the development of novel therapeutic agents, particularly kinase inhibitors. This compound is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries focused on oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex quinazoline-based active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Serves as a core scaffold for the development and screening of novel tyrosine kinase and serine/threonine kinase inhibitors.
• Oncology Drug Discovery: Used in medicinal chemistry programs targeting cancer pathways, including EGFR and VEGFR inhibitors.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of advanced drug candidates.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting research in heterocyclic chemistry and medicinal chemistry.

Basic Information

Product Name	4-Amino-6,7-dimethoxy-1H-quinazolin-2-one hydrochloride
CAS No.	134749-43-2
Molecular Formula	C10H12N4O3 • HCl
Molecular Weight	272.69 g/mol (Free base: 236.23 g/mol)
Synonyms	4-Amino-6,7-dimethoxyquinazolin-2(1H)-one hydrochloride; 2(1H)-Quinazolinone, 4-amino-6,7-dimethoxy-, hydrochloride; 6,7-Dimethoxy-4-amino-2(1H)-quinazolinone hydrochloride; PD 153035 hydrochloride (common research alias); ZD 1839 intermediate (related to Gefitinib synthesis); EGFR-TK inhibitor intermediate
EINECS	Contact for details

Quality Control

Our 4-Amino-6,7-dimethoxy-1H-quinazolin-2-one hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical R&D use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.