Description

Endothelin, Nle(7)- CAS NO 134699-39-1 is a synthetic, biologically active peptide analog of the potent vasoconstrictor endothelin-1, where the seventh amino acid (tryptophan) is replaced by norleucine (Nle). This modification enhances its stability for research applications while maintaining significant receptor binding affinity. It is a critical tool for researchers in cardiovascular and renal pharmacology, enabling the study of endothelin receptor signaling pathways, drug discovery, and the pathophysiology of hypertension and fibrosis.

Application

• Biomedical Research: Used as a stable reference standard and agonist in studies of endothelin receptor (ETA and ETB) function and signaling cascades.
• Drug Discovery & Development: Serves as a key pharmacological tool for high-throughput screening (HTS) and validation of novel endothelin receptor antagonists.
• Cardiovascular Studies: Applied in in vitro and ex vivo models to investigate vasoconstriction, vascular smooth muscle cell proliferation, and the role of endothelin in diseases like pulmonary arterial hypertension.
• Renal & Fibrosis Research: Utilized to model and study the effects of endothelin in renal pathophysiology, organ fibrosis, and related inflammatory processes.
• Academic & Institutional Laboratories: Essential reagent for basic science research in university and government research institutions focusing on peptide hormones and G-protein coupled receptors (GPCRs).
• Biopharmaceutical Manufacturing Support: Employed in quality control and assay development for therapeutics targeting the endothelin system.

Basic Information

Product Name	Endothelin, Nle(7)-
CAS No.	134699-39-1
Molecular Formula	C109H159N27O32S5
Molecular Weight	2492.9 g/mol
Synonyms	Endothelin-1, Nle(7)-; [Nle7]-Endothelin-1; Norleucine7-Endothelin-1; ET-1 (Nle7); Endothelin-1 (7-Nle); H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Trp7→Nle); [Nle7]-ET-1; Synthetic Endothelin Analog
EINECS	Contact for details

Quality Control

Our Endothelin, Nle(7)- is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity determination by HPLC and structural confirmation by mass spectrometry. A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.