Description

L-Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Phenylmethyl Ester is a protected amino acid derivative, specifically a Cbz-protected norleucine benzyl ester, serving as a crucial chiral building block in organic synthesis. Its primary value lies in providing a stable, activated form of norleucine for controlled peptide coupling and other synthetic transformations, ensuring high stereochemical purity and reaction yield. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require high-purity intermediates for drug discovery, peptide synthesis, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic peptides and peptidomimetics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to incorporate norleucine residues.
• Bioconjugation & Labeling: Acts as a precursor for creating modified amino acids used in bioconjugation strategies for drug delivery systems or diagnostic agents.
• Chemical Biology Research: Employed in the study of protein structure and function, including the preparation of isotopically labeled analogs for NMR studies.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	L-Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Phenylmethyl Ester
CAS No.	134676-78-1
Molecular Formula	C21H25NO4
Molecular Weight	355.43 g/mol
Synonyms	Nα-Cbz-L-norleucine benzyl ester; Benzyl Nα-[(benzyloxy)carbonyl]-L-norleucinate; (S)-Benzyl 2-(((benzyloxy)carbonyl)amino)hexanoate; Cbz-L-Nle-OBzl; Z-L-Norleucine-OBzl; N-Carbobenzoxy-L-norleucine benzyl ester; Nα-Carbobenzyloxy-L-norleucine benzyl ester
EINECS	Contact for details

Quality Control

Our L-Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Phenylmethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.