Description

2,4-Dichloro-6-Fluoroquinazoline is a high-purity, multi-functional halogenated quinazoline building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the chlorine and fluorine atoms serve as distinct handles for selective nucleophilic substitution, enabling the efficient construction of complex heterocyclic scaffolds. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinazoline derivatives.
• Agrochemical Research: Used as a core scaffold for developing novel herbicides, fungicides, and pesticides with enhanced efficacy.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for optoelectronic devices.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the quinazoline moiety into more complex molecular architectures.
• Dye & Pigment Intermediate: Utilized in the production of specialized fluorinated quinazoline-based dyes and colorants.
• Academic & Contract Research: A valuable reagent for methodological studies in heterocyclic and fluorine chemistry within university and CRO laboratories.

Basic Information

Product Name	2,4-Dichloro-6-Fluoroquinazoline
CAS No.	134517-57-0
Molecular Formula	C8H3Cl2FN2
Molecular Weight	217.03 g/mol
Synonyms	6-Fluoro-2,4-dichloroquinazoline; 2,4-Dichloro-6-fluoroquinazoline; Quinazoline, 2,4-dichloro-6-fluoro-; 2,4-Dichloro-6-fluor-quinazolin; 134517-57-0; 6-Fluoro-2,4-dichloro-quinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-6-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.