Description

n-Acetylheparin is a chemically modified derivative of the natural glycosaminoglycan heparin, characterized by the introduction of acetyl groups to its polysaccharide chain. This modification is crucial for creating a compound with a distinct biological profile, offering reduced anticoagulant activity while potentially retaining or enhancing other desirable therapeutic properties. It is primarily utilized in advanced pharmaceutical research and development, particularly for applications requiring heparin-like molecules with tailored biological effects.

Application

• Pharmaceutical R&D: Investigated as a potential therapeutic agent with modified anticoagulant and anti-inflammatory properties.
• Biochemical Research: Used as a tool compound to study the structure-activity relationships of heparin and its derivatives.
• Cell Culture & Tissue Engineering: Employed as a surface modifier or media supplement to influence cell growth and differentiation.
• Anticoagulant Studies: Serves as a reference or comparator in studies aiming to develop heparin derivatives with specific, reduced anticoagulant profiles.
• Drug Delivery Systems: Explored as a biocompatible carrier or targeting moiety for various therapeutic molecules.

Basic Information

Product Name	n-Acetylheparin
CAS No.	134498-62-7
Molecular Formula	Typically represented as (C14H21NO15Sn) for the repeating unit; exact formula varies with degree of acetylation and chain length.
Molecular Weight	Variable, depending on the source heparin and the degree of acetylation. Contact for details.
Synonyms	Acetylated Heparin; Heparin, acetate; N-Acetyl Heparin; O-Acetylheparin; Heparin Acetate Salt; Partially Acetylated Heparin; Chemically Modified Heparin; Low-Anticoagulant Heparin Derivative
EINECS	Contact for details.

Quality Control

Our n-Acetylheparin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Key parameters such as degree of acetylation, molecular weight distribution, and biological activity are rigorously controlled. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (as acetylated heparin)
Degree of Acetylation (NMR)	As per customer requirement
Molecular Weight (GPC)	Specified range available
Anticoagulant Activity (Anti-Factor Xa)	Significantly reduced vs. native heparin
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 0.5 EU/mg (or as required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.