Description

Fmoc-3-Iodo-L-Tyrosine CAS NO 134486-00-3 is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for introducing iodinated tyrosine residues into peptide sequences, enabling advanced research in radiopharmaceuticals, molecular imaging, and protein structure-function studies. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of iodinated tyrosine during automated peptide assembly.
• Radiopharmaceutical Precursor: Serves as a precursor for radioiodination (e.g., with I-125 or I-131) to create labeled peptides for targeted cancer therapy and diagnostic imaging.
• Bioconjugation & Probe Development: Used to synthesize peptide-based probes for studying protein-protein interactions, receptor binding, and cellular signaling pathways.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of tyrosine halogenation effects on peptide stability, bioavailability, and biological activity.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries in drug discovery campaigns.
• Academic & Industrial Research: Fundamental research tool in biochemistry, medicinal chemistry, and chemical biology for novel therapeutic development.

Basic Information

Product Name	Fmoc-3-Iodo-L-Tyrosine
CAS No.	134486-00-3
Molecular Formula	C24H20INO5
Molecular Weight	561.32 g/mol
Synonyms	Fmoc-3-Iodo-L-tyrosine; Fmoc-Tyr(3-I)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3-iodo-4-hydroxyphenyl)propanoic acid; Fmoc-3-Iodo-L-tyrosine-OH; Fmoc-L-Tyrosine(3-I); N-Fmoc-3-iodo-L-tyrosine; 3-Iodo-L-tyrosine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-3-Iodo-L-Tyrosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.