Description

1,3-Bis(n-(n-(2-Aminoethyl)-2-Aminoethyl)-2-Aminoacetamido)-2-(4-Isothiocyanatobenzyl)Propane-N,N,N',N'',N''',N'''',N''''',N'''''-Octaaceticacid is a sophisticated, high-purity polyaminocarboxylate chelating agent and bifunctional conjugation linker, primarily recognized for its role in advanced diagnostic and therapeutic applications. Its core value lies in its exceptional ability to form stable, high-affinity complexes with a wide range of metal ions, particularly lanthanides, which is critical for sensitive detection and imaging technologies. This compound is essential for researchers and manufacturers in the fields of molecular diagnostics, immunoassay development, and radiopharmaceuticals, where reliable and specific conjugation chemistry is paramount.

Application

• Time-Resolved Fluorescence (TRF) and Fluoroimmunoassays (FIA): As a key component for labeling antibodies, antigens, or oligonucleotides with lanthanide ions (e.g., Eu³⁺, Tb³⁺) to create highly sensitive, stable fluorescent probes.
• Magnetic Resonance Imaging (MRI) Contrast Agent Development: Serving as a bifunctional chelator for gadolinium (Gd³⁺) or other paramagnetic ions, enabling the covalent attachment of contrast agents to targeting biomolecules.
• Radiopharmaceuticals and Radiodiagnostics: Chelating radionuclides (e.g., ¹¹¹In, ⁶⁸Ga, ¹⁷⁷Lu) for targeted radiotherapy and positron emission tomography (PET) imaging, leveraging its isothiocyanate group for biomolecule conjugation.
• In Vitro Diagnostics (IVD) Reagent Manufacturing: A critical raw material for producing conjugated detection reagents used in automated clinical analyzers and point-of-care test devices.
• Bioconjugation and Protein Labeling: The isothiocyanate functional group reacts with primary amines, allowing for the stable covalent coupling of the chelator to proteins, peptides, and antibodies.
• Research & Development in Chelation Chemistry: Used as a model compound or starting material for developing new metal-organic frameworks (MOFs) or advanced coordination polymers in academic and industrial research settings.

Basic Information

Item	Details
Product Name	1,3-Bis(n-(n-(2-Aminoethyl)-2-Aminoethyl)-2-Aminoacetamido)-2-(4-Isothiocyanatobenzyl)Propane-N,N,N',N'',N''',N'''',N''''',N'''''-Octaaceticacid
CAS No.	134439-56-8
Molecular Formula	C₄₀H₆₂N₁₀O₁₈S
Molecular Weight	1003.04 g/mol
Synonyms	Benzyl-ITC-DTPA; p-SCN-Bn-DTPA; 2-(4-Isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid derivative; Bifunctional DTPA Isothiocyanate; DTPA-bz-isothiocyanate; 1,3-Bis[N-(2-aminoethyl)-N-(carboxymethyl)amino]-2-(4-isothiocyanatobenzyl)propane-N,N,N',N'',N''',N'''',N''''',N'''''-octaacetic acid; (p-Isothiocyanatobenzyl)-DTPA; DTPA-Bn-NCS
EINECS	Contact for details

Quality Control

Our production of this high-value chelator adheres to stringent quality protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized using advanced analytical techniques including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide comprehensive Certificates of Analysis (COA) detailing specifications for purity, metal content, and functional group activity. Our quality system is designed to support applications requiring GMP-grade materials for diagnostic and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Functional Group (Isothiocyanate)	≥ 85% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.