Description

Tolcapone is a potent and selective catechol-O-methyltransferase (COMT) inhibitor used in pharmaceutical synthesis. This compound is critical for the development of advanced therapeutic agents targeting neurological disorders. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for Parkinson's disease.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of anti-Parkinson's medications.
• Key intermediate in advanced neurological drug research and development.
• Reference standard for analytical and quality control laboratories.
• Biochemical research tool for studying catecholamine metabolism and COMT enzyme activity.
• Precursor in the synthesis of novel therapeutic agents targeting the central nervous system.

Basic Information

Product Name	Tolcapone
CAS No.	134308-13-7
Molecular Formula	C14H11NO5
Molecular Weight	273.24 g/mol
Synonyms	3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone; Ro 40-7592; Tasmar (brand name); (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; COMT Inhibitor Tolcapone; 4-Methyl-3,4-dihydroxy-5-nitrobenzophenone
EINECS	Contact for details

Quality Control

Our Tolcapone is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant GMP guidelines and can supply material suitable for use as a reference standard or API intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.