Description

Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Methyl Ester is a protected amino acid derivative, specifically the methyl ester of N-Carbobenzoxy-L-norleucine. This compound is a critical building block in peptide synthesis, where it serves to protect the amine functionality of norleucine, preventing unwanted side reactions during coupling steps. It is primarily needed by pharmaceutical researchers, peptide chemists, and fine chemical manufacturers engaged in the development of novel therapeutic peptides and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the controlled incorporation of norleucine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling methodologies for research-scale and small-batch production.
• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Employed in studies involving protein structure, function, and the creation of peptide analogs or labeled peptides.
• Fine Chemical Synthesis: Serves as a chiral synthon for constructing more complex organic molecules with specific stereochemistry.
• Reference Standard: Used as a high-purity standard in analytical laboratories for method development and quality control of peptide products.

Basic Information

Product Name	Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Methyl Ester
CAS No.	134306-35-7
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	N-Cbz-L-norleucine methyl ester; Methyl N-[(benzyloxy)carbonyl]-L-norleucinate; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)hexanoate; Z-L-Nle-OMe; Cbz-L-Norleucine-OMe; L-Norleucine, N-[(phenylmethoxy)carbonyl]-, methyl ester; Methyl N-carbobenzoxy-L-norleucinate
EINECS	Contact for details

Quality Control

Our Norleucine, n-[(Phenylmethoxy)Carbonyl]-, Methyl Ester is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.