Description

Hirudin Hv3 is a highly specific, potent, and direct thrombin inhibitor derived from the salivary glands of the medicinal leech, *Hirudo medicinalis*. This compound is critical for research and development in the life sciences, particularly for studying hemostasis, thrombosis, and anticoagulant mechanisms. It is primarily utilized by pharmaceutical researchers, diagnostic kit manufacturers, and academic institutions focused on cardiovascular and hematological studies.

Application

• Biomedical Research: As a key reagent for studying blood coagulation pathways, platelet aggregation, and thrombosis models in vitro and in vivo.
• Diagnostic Development: Used in the formulation of control reagents and calibrators for clinical assays measuring thrombin activity, clotting times, and other hemostatic parameters.
• Pharmaceutical R&D: Serves as a reference standard and a lead compound in the discovery and development of novel anticoagulant and antithrombotic therapeutics.
• Biochemical Studies: Employed to specifically inhibit thrombin in enzymatic assays, protein interaction studies, and structural biology research.
• Medical Device Coating: Investigated for surface modification of stents, catheters, and other blood-contacting devices to prevent clot formation and improve biocompatibility.

Basic Information

Product Name	Hirudin Hv3
CAS No.	134289-40-0
Molecular Formula	C181H263N49O55
Molecular Weight	Approx. 6963.5 g/mol
Synonyms	Hirudin Variant 3; Hirugen; Recombinant Hirudin (variant 3); HV-3; Thrombin Inhibitor (Hirudin-derived); Leech-derived Anticoagulant Peptide; Hirudo medicinalis Anticoagulant; Antithrombin I
EINECS	Contact for details

Quality Control

Our Hirudin Hv3 is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as purity by HPLC, peptide content, specific activity, and endotoxin levels. We support research and development requiring high-purity biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Specific Activity	≥ 12,000 ATU/mg
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.