Description

S-Benzyl-n-Malonylcysteine is a specialized cysteine derivative characterized by its S-benzyl and N-malonyl protecting groups. This compound is of significant value in advanced organic synthesis and pharmaceutical research, particularly for the controlled construction and modification of peptides and proteins. It serves as a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, protected amino acid intermediates for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key protected amino acid precursor in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Used for site-specific protein and antibody modification, enabling the development of antibody-drug conjugates (ADCs) and diagnostic probes.
• Peptide Synthesis: Serves as a crucial building block in solid-phase and solution-phase peptide synthesis (SPPS) to introduce cysteine residues with orthogonal protection.
• Biochemical Research: Employed in studying enzyme mechanisms, protein folding, and disulfide bridge formation due to its selectively protected thiol and amine functionalities.
• Protecting Group Strategy: Utilized in multi-step synthetic routes where the malonyl and benzyl groups provide stability under specific reaction conditions.
• Material Science: Potential applications in creating functionalized surfaces or polymers through thiol-mediated coupling reactions.

Basic Information

Product Name	S-Benzyl-n-Malonylcysteine
CAS No.	134283-03-7
Molecular Formula	C13H15NO5S
Molecular Weight	297.33 g/mol
Synonyms	N-Malonyl-S-benzyl-L-cysteine; S-Benzyl-N-malonylcysteine; L-Cysteine, N-(1,3-dicarboxypropyl)-S-(phenylmethyl)-; (2R)-2-(1,3-Dicarboxypropanamido)-3-(phenylmethylsulfanyl)propanoic acid; S-Benzyl-N-malonyl-L-cysteine; Malonyl-S-benzylcysteine; Protected Cysteine Derivative
EINECS	Contact for details

Quality Control

Our S-Benzyl-n-Malonylcysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and temperature monitoring.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.