Description

L-Aspartic Acid, 2-(Hydroxymethyl)- (9Ci) is a functionalized derivative of the amino acid L-aspartic acid, featuring an additional hydroxymethyl group. This modification imparts unique chemical properties, making it a valuable chiral building block and intermediate for advanced synthesis. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries. Its structure is ideal for creating novel peptides, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a polar, functionalized aspartic acid residue, influencing peptide conformation and bioactivity.
• Agrochemical Research: Acts as a precursor for developing novel herbicides, fungicides, and plant growth regulators with potentially improved selectivity and environmental profiles.
• Bioconjugation & Linker Chemistry: The hydroxymethyl group provides a handle for conjugation to other molecules, polymers, or surfaces in drug delivery systems and diagnostic agents.
• Enzyme Inhibitor Design: Utilized in medicinal chemistry to design transition-state analogs and mechanism-based inhibitors targeting aspartic proteases and other enzymes.
• Specialty Chemical Synthesis: Employed in the production of advanced materials, chiral ligands for catalysis, and complex natural product analogs.

Basic Information

Product Name	L-Aspartic Acid, 2-(Hydroxymethyl)- (9Ci)
CAS No.	134234-61-0
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	(2S)-2-Amino-3-(hydroxymethoxy)-3-oxopropanoic acid; 2-(Hydroxymethyl)-L-aspartic acid; L-2-(Hydroxymethyl)aspartic acid; (S)-2-Amino-3-(hydroxymethoxy)-3-oxopropanoic acid; 3-(Hydroxymethoxy)-L-aspartic acid; L-erythro-3-(Hydroxymethoxy)aspartic acid; β-Hydroxymethyl-L-aspartic acid
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid, 2-(Hydroxymethyl)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.