Description

3',4'-Dideoxy-3'-Fluorokanamycin A is a chemically modified derivative of the aminoglycoside antibiotic kanamycin A, designed to overcome specific bacterial resistance mechanisms. This semi-synthetic compound is of significant interest in pharmaceutical research for the development of next-generation antibacterial agents. It serves as a critical intermediate and reference standard for researchers and manufacturers in the antibiotic development sector, particularly those targeting resistant Gram-negative infections.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, potent aminoglycoside antibiotics.
• Antibacterial Research: Used as a reference compound in microbiological and biochemical studies to investigate structure-activity relationships (SAR) and resistance mechanisms.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.
• Mechanistic Studies: Employed in research to understand the interaction of modified aminoglycosides with bacterial ribosomes and resistance enzymes like aminoglycoside-modifying enzymes.
• Pre-clinical Development: Utilized in in vitro and in vivo studies to evaluate the efficacy, toxicity, and pharmacokinetic profiles of new antibiotic candidates.

Basic Information

Product Name	3',4'-Dideoxy-3'-Fluorokanamycin A
CAS No.	134160-38-6
Molecular Formula	C18H36FN5O9
Molecular Weight	485.51 g/mol
Synonyms	3'-Deoxy-3'-fluorokanamycin A; 3'-Fluoro-3',4'-dideoxykanamycin A; 3'-Fluorokanamycin A derivative; 1-N-[(2S,3S,4R,5S)-5-Amino-2-fluoromethyl-3,4-dihydroxytetrahydro-2-furyl]-3-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine; Fluorokanamycin derivative; Antibacterial research compound; Kanamycin A fluorinated analog
EINECS	Contact for details

Quality Control

Every batch of 3',4'-Dideoxy-3'-Fluorokanamycin A is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC), related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.