Description

L-Glutamic-2-13C Acid is a stable isotope-labeled analog of the essential amino acid L-glutamic acid, specifically enriched with carbon-13 at the 2-position. This compound is a critical tool in metabolic research, enabling precise tracking and quantification of glutamic acid pathways using advanced analytical techniques like mass spectrometry and NMR. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in tracer studies, drug metabolism and pharmacokinetics (DMPK) research, and proteomic analysis.

Application

• Metabolic Tracer Studies: Used to elucidate biochemical pathways, flux analysis, and metabolic profiling in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard for the accurate quantification of glutamic acid and related metabolites in bioanalytical assays during drug development.
• Proteomics & Biomarker Research: Enables stable isotope labeling by amino acids in cell culture (SILAC) for quantitative protein analysis and biomarker discovery.
• NMR Spectroscopy: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of proteins, enzymes, and metabolic networks.
• Clinical Diagnostics Research: Investigated for use in advanced diagnostic assays to understand disorders related to glutamate metabolism.
• Nutritional Science: Applied in studies investigating amino acid absorption, utilization, and turnover in nutritional research.

Basic Information

Product Name	L-Glutamic-2-13C Acid
CAS No.	133883-00-8
Molecular Formula	C413CH9NO4
Molecular Weight	148.10 g/mol (approx.)
Synonyms	(2S)-2-Amino-2-(13C)pentanedioic acid; L-(2-13C)Glutamic Acid; (S)-2-Amino-2-(13C)glutaric acid; L-Glutamic-2-13C Acid; Glutamic Acid-2-13C; [2-13C]-L-Glutamic Acid; H-Glu-2-13C-OH; 13C Labeled L-Glutamic Acid
EINECS	Contact for details

Quality Control

Our L-Glutamic-2-13C Acid is manufactured under strict quality systems to ensure high isotopic and chemical purity, essential for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity (HPLC), chiral purity, and residual solvent content. We adhere to relevant industry standards for stable isotope-labeled compounds to ensure batch-to-batch consistency and reliability for your long-term studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.