Description

Enkephalinamide, Tyr(1)-Psi-(Methyleneoxy)-Gly(2)-Leu(5)- is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, incorporating a psi-(methyleneoxy) backbone modification between the Tyr(1) and Gly(2) residues. This engineered structure is designed to enhance metabolic stability and receptor binding affinity, making it a critical tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on central nervous system (CNS) drug discovery, opioid receptor studies, and peptide-based therapeutic development.

Application

• Neuroscience Research: As a potent and stable ligand for probing delta (δ) and mu (μ) opioid receptor subtypes in vitro and in vivo.
• Drug Discovery & Development: Serving as a lead compound or reference standard in the design of novel, non-addictive analgesics and neuroprotective agents.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and signal transduction studies to understand opioid pathways.
• Peptide Chemistry Studies: A model compound for investigating the effects of backbone modifications (psi-analogs) on peptide conformation, stability, and bioactivity.
• Academic & Institutional Research: Fundamental research into pain mechanisms, addiction, and the physiological roles of enkephalins.

Basic Information

Product Name	Enkephalinamide, Tyr(1)-Psi-(Methyleneoxy)-Gly(2)-Leu(5)-
CAS No.	133851-90-8
Molecular Formula	C34H48N6O8
Molecular Weight	668.78 g/mol
Synonyms	Tyr-psi[CH2O]-Gly-Leu-enkephalinamide; [ψ(CH2O)]-Tyr-Gly-Leu-enkephalinamide; H-Tyr-ψ[CH2O]-Gly-Phe-Leu-NH2; Tyr-Gly psi-methyleneoxy pseudopeptide Leu-enkephalinamide; Modified Leu-Enkephalinamide; Opioid Receptor Pseudopeptide Ligand; (2S)-2-[[(2S)-2-[[2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]oxymethyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
EINECS	Contact for details

Quality Control

Every batch of Enkephalinamide, Tyr(1)-Psi-(Methyleneoxy)-Gly(2)-Leu(5)- is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), peptide content, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.