Description

Atrial Natriuretic Factor (5-25), I-Tyr(0)- CAS NO 133849-97-5 is a synthetic peptide fragment corresponding to the biologically active core of the human atrial natriuretic peptide (ANP). This high-purity reference standard is critical for cardiovascular research and diagnostic assay development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and in vitro diagnostic (IVD) manufacturers for studying natriuresis, vasodilation, and the renin-angiotensin-aldosterone system.

Application

• Biomedical Research Standard: Used as a primary reference standard in quantitative assays for ANP and related peptides.
• Cardiovascular Disease Studies: Essential for investigating heart failure, hypertension, and renal function in preclinical models.
• Diagnostic Kit Development: A key component in the calibration and validation of ELISA and RIA kits for cardiac biomarker detection.
• Receptor Binding Assays: Employed in studies to characterize and quantify natriuretic peptide receptors (NPR-A, NPR-B).
• Pharmaceutical QC: Serves as a system suitability standard in the quality control of therapeutic peptides targeting cardiovascular pathways.
• Metabolic Pathway Analysis: Used to elucidate the role of ANP in sodium homeostasis and water balance.

Basic Information

Product Name	Atrial Natriuretic Factor (5-25), I-Tyr(0)- CAS NO 133849-97-5
CAS No.	133849-97-5
Molecular Formula	C106H165N33O34S2
Molecular Weight	2414.8 g/mol
Synonyms	ANF (5-25), I-Tyr(0)-; Atrial Natriuretic Peptide (5-25), Iodo-Tyrosine(0); hANP (5-25); Cardionatrin (5-25); Atriopeptin (5-25); ANP (5-25); 3-Iodo-L-tyrosyl-atrial natriuretic factor (5-25) (human); 133849-97-5
EINECS	Contact for details

Quality Control

Every batch of Atrial Natriuretic Factor (5-25), I-Tyr(0)- is manufactured under strict quality systems and undergoes comprehensive analytical characterization. Our products are supplied with a detailed Certificate of Analysis (COA) providing data for identity, purity (by HPLC), peptide content, and related substances. We adhere to high standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.