Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[2-[(Dimethylamino)Methyl]-4-Morpholinyl]-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel fluoroquinolone antibiotics, offering critical structural features for potent antimicrobial activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antibacterial compounds with improved efficacy and safety profiles.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold in the development and scale-up processes for new antibiotic APIs.
• Chemical Synthesis Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Biochemical Research: Used in studies investigating the mechanism of action of topoisomerase inhibitors and bacterial DNA gyrase.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[2-[(Dimethylamino)Methyl]-4-Morpholinyl]-6-Fluoro-1,4-Dihydro-8-Methoxy-4-Oxo-
CAS No.	133762-22-8
Molecular Formula	C23H28FN3O5
Molecular Weight	445.49 g/mol
Synonyms	1-Cyclopropyl-7-[2-[(dimethylamino)methyl]-4-morpholinyl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid derivative; 8-Methoxy Gatifloxacin Intermediate; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid precursor
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent specifications required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.