Description

Pagoclone CAS NO 133737-48-1 is a synthetic organic compound belonging to the cyclopyrrolone class, structurally related to zopiclone. This compound is of significant interest in pharmaceutical research and development due to its pharmacological profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) active agents.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in drug development and manufacturing.
• Preclinical Research: Used in biochemical and pharmacological studies to investigate mechanisms of action related to GABAA receptor modulation.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor or building block in the production pathway of advanced pharmaceutical compounds.
• Metabolite Studies: Employed in the identification and quantification of metabolites during pharmacokinetic and toxicological research.
• Analytical Method Development: Critical for developing and calibrating analytical techniques such as HPLC, LC-MS, and NMR in analytical laboratories.

Basic Information

Product Name	Pagoclone
CAS No.	133737-48-1
Molecular Formula	C20H19ClN2O3
Molecular Weight	370.83 g/mol
Synonyms	Pagoclone; (S)-Pagoclone; 6-(o-Chlorophenyl)-2,4-dihydro-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-one; RP 62203; Imidazo[1,2-a][1,4]benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-, (2S)-
EINECS	Contact for details

Quality Control

Our Pagoclone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.