Description

4-Methoxybenzyloxycarbonyl-Asparaginyl-Leucyl-Glycine Ethyl Ester is a protected tripeptide derivative, a crucial building block in solid-phase peptide synthesis (SPPS). Its value lies in providing a precisely defined sequence with orthogonal protecting groups, enabling the controlled construction of complex peptides and proteins. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of longer, biologically active peptide sequences in drug discovery and development.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected fragment for the efficient, sequential assembly of custom peptides on resin.
• Biochemical Research: Used in academic and industrial R&D to study protein structure-function relationships, enzyme substrates, and receptor ligands.
• Peptide Library Construction: A defined component for generating combinatorial libraries used in high-throughput screening for new drug candidates.
• API Synthesis: Intermediate in the multi-step production of Active Pharmaceutical Ingredients (APIs) for peptide-based therapeutics.
• Conjugate Chemistry: The reactive termini allow for conjugation to other molecules, such as dyes, polymers, or carrier proteins, for diagnostic or targeted delivery applications.

Basic Information

Product Name	4-Methoxybenzyloxycarbonyl-Asparaginyl-Leucyl-Glycine Ethyl Ester
CAS No.	133665-58-4
Molecular Formula	C26H38N4O9
Molecular Weight	550.60 g/mol
Synonyms	Z-Asn-Leu-Gly-OEt; Moz-Asn-Leu-Gly-OEt; 4-Methoxybenzyloxycarbonyl-L-asparaginyl-L-leucyl-glycine ethyl ester; Nα-(4-Methoxybenzyloxycarbonyl)-L-asparaginyl-L-leucylglycine ethyl ester; Cbz-Asn-Leu-Gly-OEt (common abbreviation); Asparaginyl-leucyl-glycine ethyl ester, N-[(4-methoxyphenyl)methoxy]carbonyl]-; Protected Asn-Leu-Gly Tripeptide; Peptide Synthesis Building Block 133665-58-4
EINECS	Contact for details

Quality Control

Our peptide intermediates are produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical development, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature, typically between 2°C and 8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect purity and reactivity. Handle under an inert atmosphere if specified for sensitive applications.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.