Description

H-Asp(Amc)-Oh is a specialized amino acid derivative, specifically an aspartic acid analog containing an amidomethylcoumarin (Amc) group. This compound is a critical fluorogenic substrate and a key building block in the synthesis of advanced peptide-based reagents for biochemical research. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, well-characterized intermediates for protease assay development and proteomics research.

Application

• Protease/Enzyme Substrate: Primarily used as a fluorogenic substrate for the study and quantification of various aspartic proteases and other hydrolytic enzymes.
• Biochemical Research Reagent: Serves as a key intermediate in the development of sensitive assay kits for enzyme activity and inhibition studies.
• Peptide Synthesis: Employed as a specialized, protected amino acid building block in solid-phase and solution-phase peptide synthesis for research purposes.
• Diagnostic Development: Used in the research and development phase of diagnostic assays targeting specific enzymatic pathways.
• Pharmaceutical Research: Acts as a tool compound in drug discovery programs focused on protease targets, aiding in high-throughput screening and mechanistic studies.

Basic Information

Product Name	H-Asp(Amc)-Oh
CAS No.	133628-73-6
Molecular Formula	C₁₄H₁₄N₂O₆
Molecular Weight	306.27 g/mol
Synonyms	Aspartic acid β-(7-amido-4-methylcoumarin); L-Aspartic acid 4-methylcoumaryl-7-amide; Asp-AMC; H-Asp-AMC-OH; 7-Amido-4-methylcoumarin conjugate of L-aspartic acid; Fluorogenic substrate for aspartic proteases; L-Asp-AMC; Aspartic acid-AMC
EINECS	Contact for details

Quality Control

Our H-Asp(Amc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, chiral purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.