Description

Fmoc-Aspartimol(Otbu) CAS NO 133565-45-4 is a protected aspartic acid derivative, specifically an Fmoc-protected aspartic acid β-tert-butyl ester, widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the aspartic acid side chain, preventing unwanted side reactions during the assembly of complex peptide sequences. This high-purity amino acid derivative is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the controlled incorporation of aspartic acid into custom peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Serves as a versatile monomer for creating diverse arrays of compounds for high-throughput screening.
• Bioconjugation & Labeling: The reactive carboxyl group, after deprotection, can be used for coupling peptides to other molecules, surfaces, or fluorescent tags.
• Academic & Institutional Research: Fundamental reagent for studying protein structure-function relationships, peptide hormones, and signal transduction pathways.
• Production of Protected Peptide Fragments: Enables the synthesis of complex, side-chain-protected peptide intermediates for fragment condensation strategies.

Basic Information

Item	Detail
Product Name	Fmoc-Aspartimol(Otbu)
CAS No.	133565-45-4
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-Asp(OtBu)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-tert-butyl ester; Fmoc-L-Aspartic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-tert-butyl ester; Fmoc-Aspartic acid β-tert-butyl ester; Fmoc-Asp(OtBu); Nα-Fmoc-L-aspartic acid β-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Aspartimol(Otbu) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A Certificate of Analysis (COA) detailing specific results for identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.