Description

Boc-Thr(Bzl)-Ol CAS NO 133565-43-2 is a protected amino acid derivative, specifically the benzyl-protected threonine with a tert-butoxycarbonyl (Boc) group on the amine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of threonine residues in peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide tags, probes, and linkers for bioconjugation chemistry.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Essential for fundamental studies in biochemistry, molecular biology, and medicinal chemistry involving peptide structure and function.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering custom peptide synthesis services.

Basic Information

Product Name	Boc-Thr(Bzl)-Ol
CAS No.	133565-43-2
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine; Boc-O-benzyl-L-threonine; Boc-L-Thr(Bzl)-OH; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-(benzyloxy)butanoic acid; tert-Butyl (2S,3R)-2-amino-3-(benzyloxy)butanoate; Boc-Thr(OBzl)-OH; BOC-THR(BZL)-OH; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, 3-(phenylmethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Thr(Bzl)-Ol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.