Description

Exendin-3 (9-39) Amide is a high-purity synthetic peptide fragment that acts as a potent and selective antagonist of the glucagon-like peptide-1 (GLP-1) receptor. This specific pharmacological activity makes it an invaluable research tool for studying metabolic pathways, insulin secretion, and the physiological roles of GLP-1. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on diabetes, obesity, and metabolic disorder research.

Application

• Pharmacological Research: Used as a selective GLP-1 receptor antagonist to delineate receptor function and signaling pathways in vitro and in vivo.
• Metabolic Disease Studies: Critical for investigating the mechanisms of glucose homeostasis, insulin secretion, and appetite regulation related to diabetes and obesity.
• Drug Discovery & Development: Serves as a reference standard and tool compound for screening and validating new therapeutic candidates targeting the GLP-1 receptor.
• Academic & Biomedical Research: Employed in university and institutional labs for basic science research into endocrinology and peptide hormone action.
• Biochemical Assay Development: Used to establish and validate competitive binding assays and functional cellular assays for GLP-1 receptor activity.

Basic Information

Product Name	Exendin-3 (9-39) Amide
CAS No.	133514-43-9
Molecular Formula	C142H228N42O43S
Molecular Weight	3364.6 g/mol
Synonyms	Exendin (9-39) amide; Exendin 3 (9-39) amide; [Des-His1,Glu9]Exendin-3 (9-39) amide; GLP-1 (7-36) amide antagonist; Exendin-3 fragment 9-39 amide; H-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (Sequence); GLP-1 receptor antagonist (9-39)
EINECS	Contact for details

Quality Control

Our Exendin-3 (9-39) Amide is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to high standards suitable for research use, with specifications typically meeting or exceeding 95% purity as determined by analytical HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.