Description

Fmoc-Glu(Oall)-Oh CAS NO 133464-46-7 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) and O-allyl (Oall) protected form of glutamic acid. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of peptides, utilizing the Fmoc protection strategy.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Proteomics & Biochemistry: Used in the study of protein structure, function, and interactions by incorporating modified amino acids.
• Custom Peptide Services: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering custom peptide production.

Basic Information

Product Name	Fmoc-Glu(Oall)-Oh
CAS No.	133464-46-7
Molecular Formula	C24H25NO6
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-L-glutamic acid 1-allyl ester; Fmoc-Glu(OAll)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 1-allyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 1-allyl ester; Fmoc-L-Glu(OAll)-OH; Fmoc-Glu(OAllyl)-OH; Nα-Fmoc-L-glutamic acid γ-allyl ester; Allyl Nα-Fmoc-L-glutamate
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Oall)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.