Description

Eglin C (42-45)-Methyl Ester is a synthetic peptide derivative with specific protease inhibitory activity. This compound is a valuable intermediate and research tool in the development of therapeutic agents targeting inflammatory and proteolytic pathways. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on immunology, respiratory diseases, and enzyme mechanism studies.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel elastase and protease inhibitors for therapeutic applications.
• Biochemical Research: Used as a specific inhibitor to study the role of human leukocyte elastase (HLE) and related serine proteases in disease models.
• Inflammation & Immunology Studies: Employed in vitro and in vivo to investigate pathways involved in chronic obstructive pulmonary disease (COPD), cystic fibrosis, and acute respiratory distress syndrome (ARDS).
• Enzyme Kinetics & Mechanism: Serves as a substrate analog and competitive inhibitor for detailed enzymatic studies and high-throughput screening assays.
• Peptide Chemistry & Custom Synthesis: A building block for the custom synthesis of more complex peptide-based drug candidates and bioconjugates.

Basic Information

Product Name	Eglin C (42-45)-Methyl Ester
CAS No.	133463-25-9
Molecular Formula	C22H38N6O7
Molecular Weight	498.57 g/mol
Synonyms	Eglin c (42-45) methyl ester; L-Leucyl-L-α-aspartyl-L-prolyl-L-valine methyl ester; Leu-Asp-Pro-Val-OMe; H-Leu-Asp-Pro-Val-OMe; Eglin C fragment (42-45) methyl ester; Protease inhibitor peptide fragment; Elastase inhibitor peptide derivative
EINECS	Contact for details

Quality Control

Our Eglin C (42-45)-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.