Description

n-[(3A,5B,7B)-7-Hydroxy-24-Oxo-3-(Sulfooxy)Cholan-24-Yl]-Glycine is a chemically modified bile acid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its value lies in its specific functional groups, which make it a crucial building block for creating targeted therapeutic agents. This high-purity intermediate is primarily needed by research institutions and pharmaceutical manufacturers developing novel drug candidates, particularly in the fields of metabolic and liver disease treatment.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel therapeutic agents, particularly for metabolic and hepatobiliary disorders.
• Biochemical Research: Used as a reference standard or a key reagent in studies involving bile acid metabolism, receptor binding, and signal transduction pathways.
• Prodrug Development: Serves as a chemical scaffold for creating prodrugs with enhanced bioavailability or targeted delivery profiles.
• Enzyme Substrate/Analogue: Employed in enzymatic studies and assays to investigate the activity of enzymes involved in steroid and bile acid transformations.
• Chemical Synthesis Building Block: Utilized in organic synthesis for the introduction of specific sulfated and glycine-conjugated functionalities into complex molecular architectures.

Basic Information

Product Name	n-[(3A,5B,7B)-7-Hydroxy-24-Oxo-3-(Sulfooxy)Cholan-24-Yl]-Glycine
CAS No.	133429-88-6
Molecular Formula	C₂₆H₄₁NO₉S
Molecular Weight	543.67 g/mol
Synonyms	Glyco-7α-hydroxy-3-sulfooxy-24-oxo-5β-cholan-24-ate; 3α-Sulfooxy-7α-hydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide; 7α-Hydroxy-3α-sulfooxy-5β-cholan-24-oic acid glycine conjugate; Tauro-7α-hydroxy-3-sulfate-5β-cholan-24-oate analogue; Glycine-conjugated 3-sulfated-7-hydroxy-24-oxo bile acid; 3-Sulfate-7-hydroxy-N-glycinyl-5β-cholan-24-amide; 24-Oxo-7α-hydroxy-3α-sulfooxy-5β-cholan-24-yl-glycine
EINECS	Contact for details

Quality Control

Our n-[(3A,5B,7B)-7-Hydroxy-24-Oxo-3-(Sulfooxy)Cholan-24-Yl]-Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.