Description

Fmoc-n-Me-Tyr(Tbu)-Oh CAS NO 133373-24-7 is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing modified tyrosine residues into peptide chains, enabling the research and development of novel therapeutic peptides with enhanced stability and biological activity. It is an essential building block for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide-based drug discovery, proteomics, and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key N-Fmoc protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the development of peptide therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug delivery systems.
• Chemical Biology & Proteomics: Enables the site-specific incorporation of N-methylated tyrosine to study protein-protein interactions and create peptide probes.
• Peptide Library Construction: Facilitates the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: Serves as a fundamental reagent in university laboratories for teaching and advancing synthetic peptide chemistry.
• Bioconjugation: The reactive carboxyl and protected amine groups allow for further functionalization and conjugation strategies.

Basic Information

Product Name	Fmoc-n-Me-Tyr(Tbu)-Oh
CAS No.	133373-24-7
Molecular Formula	C30H33NO6
Molecular Weight	503.59 g/mol
Synonyms	Fmoc-N-methyl-O-tert-butyl-L-tyrosine; Fmoc-N-Me-Tyr(tBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(tert-butyl)-L-tyrosine; Fmoc-N-methyl-O-(tert-butyl)tyrosine; Fmoc-N-Me-Tyr(O-tBu)-OH; N-Fmoc-N-methyl-O-tert-butyltyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Tyr(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Optical Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.