Description

Fmoc-Ser(n-Bu)-Oh is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of O-tert-butyl-L-serine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and peptide chemistry who require high-purity, reliable intermediates for producing therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based drugs, hormones, and vaccines.
• Bioconjugation & Protein Engineering: Serves as a modified serine residue for introducing specific functional groups or labels into peptides and proteins.
• Combinatorial Chemistry Libraries: A fundamental component for generating diverse peptide libraries for high-throughput screening.
• Academic & Industrial Research: Employed in biochemical studies to investigate protein structure, function, and interactions.
• Production of Peptide Fragments: For synthesizing specific segments of larger proteins or bioactive peptides.

Basic Information

Product Name	Fmoc-Ser(n-Bu)-Oh
CAS No.	133368-40-8
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-O-tert-butyl-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-serine; Fmoc-Ser(OtBu)-OH; Fmoc-L-Serine(O-tert-butyl) ester; N-Fmoc-O-tert-butylserine; (2S)-3-[(2-Methylpropan-2-yl)oxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid; Fmoc-Ser(tBu)-OH; Fmoc-Ser(But)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(n-Bu)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Specific Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.