Description

H-His(1-Mtt)-Oh CAS NO 133367-32-5 is a protected derivative of the amino acid L-Histidine, specifically designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers who require precise control over the imidazole side chain of histidine during complex peptide assembly, preventing unwanted side reactions. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled incorporation of histidine into peptide chains.
• Pharmaceutical Research: For the synthesis of novel therapeutic peptides targeting various diseases, where histidine plays a crucial functional role.
• Bioconjugation & Labeling: Useful in creating peptide-based probes, tags, and conjugates for diagnostic and imaging applications.
• Enzyme Mimic & Catalyst Development: Serves as a precursor for constructing peptides that mimic the active sites of metalloenzymes.
• Academic & Industrial R&D: A fundamental reagent in chemistry and biochemistry laboratories for studying protein structure-function relationships.

Basic Information

Product Name	H-His(1-Mtt)-Oh
CAS No.	133367-32-5
Molecular Formula	C27H28N4O4
Molecular Weight	472.54 g/mol
Synonyms	Fmoc-His(1-Mtt)-OH; N-α-Fmoc-N-π-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-histidine; 1-Mtt-His(Fmoc)-OH; L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-π-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-; Fmoc-His(1-Methyltrityl)-OH; Fmoc-His(Mtt)-OH; Protected Histidine derivative; SPPS Histidine reagent
EINECS	Contact for details

Quality Control

Our H-His(1-Mtt)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed with modern analytical techniques including HPLC and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.