Description

7-[(3S)-3-Aminopyrrolidin-1-Yl]-1-Cyclopropyl-6,8-Difluoro-4-Oxo-Quino Line-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone carboxylic acid class. This compound is of critical importance for its role as a key building block in the synthesis of novel, potent antibacterial agents. It is primarily required by pharmaceutical R&D departments and active pharmaceutical ingredient (API) manufacturers focused on developing next-generation antibiotics to address drug-resistant bacterial infections.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced fluoroquinolone antibiotic APIs.
• Antibacterial Drug Research: Serves as a core scaffold for medicinal chemistry and structure-activity relationship (SAR) studies in antibacterial discovery programs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled, multi-step synthesis of final drug substances targeting Gram-positive and Gram-negative bacteria.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	7-[(3S)-3-Aminopyrrolidin-1-Yl]-1-Cyclopropyl-6,8-Difluoro-4-Oxo-Quino Line-3-Carboxylic Acid
CAS No.	133298-78-9
Molecular Formula	C₁₇H₁₇F₂N₃O₃
Molecular Weight	349.33 g/mol
Synonyms	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-((3S)-3-aminopyrrolidin-1-yl)-4-oxo-3-quinolinecarboxylic Acid; (3S)-7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Garenoxacin Intermediate; OPC-17116 Intermediate; T-3811 Intermediate; 7-[(3S)-3-Aminopyrrolidin-1-yl]-1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 7-[(3S)-3-Aminopyrrolidin-1-Yl]-1-Cyclopropyl-6,8-Difluoro-4-Oxo-Quino Line-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.