Description

Ademetionine 1, 4-Butane-Disulfonate is a stabilized salt form of S-adenosylmethionine (SAMe), a critical biochemical cofactor found in all living cells. This compound is essential for its role in key metabolic pathways, including methylation, transsulfuration, and aminopropylation. It is primarily utilized in the pharmaceutical and nutraceutical industries for the development of high-purity active pharmaceutical ingredients (APIs) and dietary supplements targeting liver health, joint function, and mood regulation.

Application

• Pharmaceutical API: Core ingredient in prescription and over-the-counter (OTC) medications for hepatoprotection, osteoarthritis, and depressive disorders.
• Nutraceutical Formulations: Key component in premium dietary supplements aimed at supporting liver detoxification, joint mobility, and emotional well-being.
• Biochemical Research: Used as a standard or reagent in life science research studying methylation processes, epigenetics, and cellular metabolism.
• Veterinary Medicine: Incorporated into therapeutic feeds and supplements for liver support and metabolic health in companion and production animals.
• Cosmeceutical Preparations: Potential ingredient in advanced skincare products targeting cellular renewal and antioxidant protection.

Basic Information

Product Name	Ademetionine 1, 4-Butane-Disulfonate
CAS No.	133236-03-0
Molecular Formula	C15H23N6O5S2 • C4H10O6S2
Molecular Weight	662.73 g/mol
Synonyms	S-Adenosylmethionine 1,4-Butanedisulfonate; SAMe 1,4-Butanedisulfonate; AdoMet 1,4-Butanedisulfonate; S-Adenosyl-L-methionine 1,4-Butanedisulfonate Salt; SAM-e; Ademetionine Butanedisulfonate; (3S)-5'-[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine 1,4-Butanedisulfonate
EINECS	Contact for details

Quality Control

Our Ademetionine 1, 4-Butane-Disulfonate is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical and nutraceutical use. Production adheres to current Good Manufacturing Practices (cGMP) and is supported by a comprehensive Certificate of Analysis (COA) for each batch, detailing purity, identity, and impurity profiles. We can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.