Description

Abz-Thr-Ile-Nle-p-Nitro-Phe-Gln-Arg-Nh2 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critical for researchers and developers requiring precise, real-time measurement of protease activity, particularly in high-throughput screening and biochemical research. It is primarily utilized by the pharmaceutical, biotechnology, and life sciences industries for drug discovery, enzyme kinetics studies, and diagnostic assay development.

Application

• Protease Activity Assays: As a fluorogenic substrate for the detection and quantification of specific protease enzymes.
• High-Throughput Screening (HTS): Enables rapid screening of compound libraries for protease inhibitors in drug discovery pipelines.
• Biochemical Research: Used in enzyme kinetics studies to determine kinetic parameters like Km and Vmax.
• Diagnostic Development: Serves as a key component in developing sensitive in-vitro diagnostic tests for disease biomarkers.
• Cell Biology Studies: Applied in assays to monitor protease activity within cellular pathways and signaling events.
• Quality Control in Biologics: Used to assess the presence and activity of proteases during the manufacturing of therapeutic proteins.

Basic Information

Product Name	Abz-Thr-Ile-Nle-p-Nitro-Phe-Gln-Arg-Nh2
CAS No.	133233-38-2
Molecular Formula	C48H70N14O14
Molecular Weight	1043.2 g/mol
Synonyms	Abz-Thr-Ile-Nle-pNO2-Phe-Gln-Arg-NH2; 2-Aminobenzoyl-Thr-Ile-Norleucine-4-Nitro-Phe-Gln-Arg-Amide; Fluorogenic Peptide Substrate Abz-T-I-Nle-pNF-Q-R-NH2; Protease Substrate 133233-38-2; Abz-T-I-Nle-F(NO2)-Q-R-NH2; o-Aminobenzoyl-Threonyl-Isoleucyl-Norleucyl-p-Nitro-Phenylalanyl-Glutaminyl-Argininamide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of Abz-Thr-Ile-Nle-p-Nitro-Phe-Gln-Arg-Nh2 undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97% (on dry basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.