Description

n-(2-Amino-4-Trifluoromethylphenyl)Pyrrolidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidine and trifluoromethyl-substituted aniline structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the global pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the biological activity of the trifluoromethyl group.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Organic Electronics Research: Investigated as a component for charge-transport materials and organic semiconductors due to its electron-donating amine and electron-withdrawing CF3 groups.
• Fluorescent Probe & Dye Chemistry: Utilized in the design of advanced fluorescent markers and dyes for bio-imaging and analytical applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production in fine chemical manufacturing.

Basic Information

Product Name	n-(2-Amino-4-Trifluoromethylphenyl)Pyrrolidine
CAS No.	133184-80-2
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)-N-(pyrrolidin-1-yl)aniline; 1-(2-Amino-4-(trifluoromethyl)phenyl)pyrrolidine; 2-(Pyrrolidin-1-yl)-5-(trifluoromethyl)aniline; N-(2-Amino-4-trifluoromethylphenyl)pyrrolidine; 4-Trifluoromethyl-2-pyrrolidin-1-yl-phenylamine; 2-Pyrrolidino-5-trifluoromethylaniline
EINECS	Contact for details

Quality Control

Our n-(2-Amino-4-Trifluoromethylphenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.