Description

Fmoc-L-Citrulline is a protected derivative of the non-proteinogenic amino acid L-citrulline, featuring the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amino function. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of citrulline residues, which are essential for studying post-translational modifications like citrullination. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide drug discovery, epigenetics research, and the development of diagnostic tools for autoimmune diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing citrulline.
• Peptide Drug Discovery & Development: For creating peptide-based therapeutics targeting conditions like rheumatoid arthritis, multiple sclerosis, and cancer where citrullinated proteins play a role.
• Biochemical Research: Used in enzymatic studies, particularly with Peptidyl Arginine Deiminase (PAD) enzymes, to investigate protein citrullination mechanisms.
• Antibody & Diagnostic Reagent Production: For synthesizing antigens to generate and detect anti-citrullinated protein antibodies (ACPAs), crucial in autoimmune disease diagnostics.
• Epigenetics & Proteomics Research: As a tool to study the role of citrullination in gene regulation, neutrophil extracellular trap (NET) formation, and disease pathology.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global research community.

Basic Information

Product Name	Fmoc-L-Citrulline
CAS No.	133174-15-9
Molecular Formula	C₂₁H₂₂N₂O₅
Molecular Weight	382.41 g/mol
Synonyms	Fmoc-Cit-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-citrulline; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(carbamoylamino)pentanoic acid; Fmoc-L-Cit; Fmoc-Citrulline; Nα-Fmoc-Nδ-carbamoyl-L-ornithine; Nα-Fmoc-L-citrulline; Fmoc-Cit
EINECS	Contact for details

Quality Control

Our Fmoc-L-Citrulline is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity (HPLC)	≥99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.