Description

H-D-Val-Nh2 Hcl is a high-purity, non-natural amino acid derivative, specifically the hydrochloride salt of D-Valinamide. This chiral building block is essential for the synthesis of complex peptides and peptidomimetics, offering critical control over stereochemistry and biological activity. It is primarily utilized by pharmaceutical research organizations, biotechnology companies, and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-valine residue, influencing peptide stability and conformation.
• Protease Inhibitor Development: Serves as a core component in designing inhibitors for enzymes like proteases, which are targets for various diseases.
• Bioconjugation & Labeling: The amine functionality allows for conjugation with other molecules, fluorophores, or carriers for diagnostic and research applications.
• Chemical Biology Research: Employed in studying protein-protein interactions and signal transduction pathways using modified peptide probes.
• Cosmetic Peptides: Potential use in the synthesis of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	H-D-Val-Nh2 Hcl
CAS No.	133170-58-8
Molecular Formula	C5H13ClN2O
Molecular Weight	152.62 g/mol
Synonyms	D-Valinamide hydrochloride; (R)-2-Amino-3-methylbutanamide hydrochloride; H-D-Val-NH2·HCl; D-2-Aminoisovaleramide hydrochloride; D-Val-NH2 HCl; (R)-Valinamide hydrochloride; D-Valinamide HCl; UNII-9I3B8T65MW
EINECS	Contact for details

Quality Control

Our H-D-Val-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.