Description

H-Phe-Ala-Leu-Ala-Leu-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Oh is a synthetic, linear nonapeptide derivative with defined sequence and high structural fidelity, widely employed in biochemical research and peptide-based drug development. Its precisely engineered amino acid composition confers selective binding affinity and protease resistance—critical for target validation studies and lead optimization. This compound is essential for researchers and pharmaceutical manufacturers engaged in GPCR modulation, antimicrobial peptide screening, and structure–activity relationship (SAR) analysis. It serves as a key reference standard and building block in academic labs, CROs, and API synthesis facilities worldwide.

Application

• Research-grade tool for studying lysine-rich peptide interactions with membrane receptors and ion channels
• Lead compound in the development of novel antimicrobial peptides targeting Gram-positive pathogens
• Reference standard for HPLC and LC-MS method validation in peptide purity and stability assays
• Substrate or inhibitor in enzymatic assays involving aminopeptidases and lysyl endopeptidases
• Building block for solid-phase synthesis of larger peptide conjugates and dendrimeric vaccine candidates
• Control material in preclinical pharmacokinetic studies assessing peptide absorption and metabolic clearance
• Calibrant for quantitative mass spectrometry in bioanalytical method development (e.g., LBA/LCMS workflows)
• Component in custom peptide libraries for high-throughput screening of protein–peptide interaction interfaces

Basic Information

Product Name	H-Phe-Ala-Leu-Ala-Leu-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Oh
CAS No.	133084-63-6
Molecular Formula	C119H205N31O27
Molecular Weight	2725.22 g/mol
Synonyms	H-Phe-Ala-Leu-Ala-Leu-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Ala-Leu-OH; Phe-Ala-Leu-Ala-Leu-Lys-Ala-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Leu-Lys-Lys-Ala-Leu-Lys-Lys-Ala-Leu-OH; PALALKAALKKALKKALKKALKKAL-OH; PALALKAALKKALKKALKKALKKAL-OH (free acid); FALALKALKKALKKALKKALKKAL-OH; N-(9-Fluorenylmethoxy)carbonyl-Phe-Ala-Leu-Ala-Leu-Lys(2-Cl-Z)-Ala-Leu-Lys(Boc)-Lys(Boc)-Ala-Leu-Lys(2-Cl-Z)-Lys(Boc)-Leu-Lys(2-Cl-Z)-Lys(Boc)-Ala-Leu-Lys(Boc)-Lys(Boc)-Ala-Leu-OH (precursor form); Peptide 133084-63-6; CAS 133084-63-6 peptide
EINECS	Not listed (not required for synthetic peptides under current EINECS scope)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (by HPLC retention time matching and MS confirmation), purity (≥95.0% by HPLC), and absence of microbial contamination (bioburden <10 CFU/g). Testing adheres to ICH Q5, Q6A, and USP Chapter <1051> Peptides guidelines. Custom QC packages—including residual solvents (ICH Q3C), heavy metals (USP <231>), and chiral purity—are available for regulated pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation. Due to its hygroscopic nature, maintain relative humidity below 30% and avoid repeated exposure to ambient air. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (MS)	[M+H]+ at m/z 2726.2 ± 0.5
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Single impurity ≤1.0%; Total impurities ≤3.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
pH (1% w/v aqueous solution)	5.5–7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.