Description

α-(β-Alanyl)Hypusine is a specialized, biologically active derivative of the rare amino acid hypusine. This compound is of significant interest in biochemical research due to its role as a precursor or intermediate in the study of eukaryotic translation initiation factor 5A (eIF5A) modification. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in advanced studies of cell growth, proliferation, and related metabolic pathways.

Application

• Biochemical Research: Critical intermediate for studying the hypusination pathway of eIF5A, a key protein in cell growth and differentiation.
• Pharmaceutical Development: Used in R&D for investigating novel therapeutic targets related to cell proliferation, including in oncology and virology.
• Enzymology Studies: Serves as a substrate or reference standard for research on deoxyhypusine synthase and deoxyhypusine hydroxylase enzymes.
• Metabolic Pathway Analysis: Employed in tracing and understanding the biosynthesis and function of hypusine-containing proteins.
• Reference Standard: High-purity grade used as a certified reference material (CRM) for analytical method development and validation in laboratories.
• Academic Research: Fundamental tool in university and institutional labs for molecular biology and post-translational modification studies.

Basic Information

Product Name	α-(β-Alanyl)Hypusine
CAS No.	133083-20-2
Molecular Formula	C11H22N4O4
Molecular Weight	274.32 g/mol
Synonyms	N6-(4-Amino-2-hydroxybutyl)-2,6-diaminohexanoic Acid, β-Alanyl Derivative; (2S)-2-Amino-6-[[(2R)-4-Amino-2-hydroxybutyl]amino]hexanoic Acid; Hypusine, N2-(3-Aminopropionyl)-; N2-(3-Aminopropionyl)hypusine; α-(β-Alanyl)hypusine; eIF5A Biosynthesis Intermediate
EINECS	Contact for details

Quality Control

Our α-(β-Alanyl)Hypusine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and chiral purity analysis to ensure structural integrity and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting research reproducibility and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.