Description

4-Bromo-3-Fluorobenzaldehyde is a versatile halogenated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromo-fluoro substitution pattern can enhance target binding and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Liquid Crystal and OLED Materials: An important building block for synthesizing fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), enabling rapid diversification of molecular structures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction methodologies and constructing complex molecular libraries for screening.

Basic Information

Product Name	4-Bromo-3-Fluorobenzaldehyde
CAS No.	133059-43-5
Molecular Formula	C7H4BrFO
Molecular Weight	203.01 g/mol
Synonyms	3-Fluoro-4-bromobenzaldehyde; 4-Bromo-3-fluorobenzenecarboxaldehyde; 3-Fluoro-4-bromobenzenecarboxaldehyde; 4-Bromo-3-fluorobenzene-1-carbaldehyde; 1-Bromo-2-fluoro-4-formylbenzene; NSC 405122; Benzaldehyde, 4-bromo-3-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorobenzaldehyde is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support our clients' regulatory needs for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.