Description

N,N'-Bis[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Lysine Pentafluorophenyl Ester is a highly specialized, activated amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides a protected lysine side chain with an active ester group, enabling efficient and controlled coupling reactions to construct complex peptides and bioconjugates. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-purity intermediates for producing therapeutic peptides, diagnostic agents, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected lysine derivative with a pentafluorophenyl (Pfp) ester activating group for efficient amide bond formation.
• Therapeutic Peptide Production: For the synthesis of peptide-based drug candidates, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Labeling: Used to introduce lysine residues with orthogonal protection for subsequent attachment of labels, tags, or payloads to proteins and other biomolecules.
• Combinatorial Chemistry: A valuable reagent in libraries for drug discovery, enabling the rapid assembly of diverse peptide structures.
• Research & Development: For academic and industrial R&D focused on peptide chemistry, protein engineering, and chemical biology studies.
• Production of Peptide Fragments: In the synthesis of specific peptide sequences used as antigens, standards, or intermediates for larger protein constructs.

Basic Information

Product Name	N,N'-Bis[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Lysine Pentafluorophenyl Ester
CAS No.	132990-14-8
Molecular Formula	C43H35F5N2O7
Molecular Weight	786.75 g/mol
Synonyms	Fmoc-Lys(Fmoc)-OPfp; Nα,Nε-Bis(9-fluorenylmethoxycarbonyl)-L-lysine pentafluorophenyl ester; Fmoc-Lys(Fmoc)-O-Pfp; Lysine, N2,N6-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(pentafluorophenyl) ester, L-; Fmoc-Lys(Fmoc)-Pfp ester; (S)-2,6-Bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Lys(Fmoc)-OPfp ester; Fmoc-L-Lys(Fmoc)-OPfp
EINECS	Contact for details

Quality Control

Our N,N'-Bis[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Lysine Pentafluorophenyl Ester is manufactured under strict quality systems to ensure high chemical purity and batch-to-batch consistency suitable for sensitive research and cGMP-guided production. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.