Description

4-Chlorothreonine is a non-proteinogenic amino acid derivative of threonine, characterized by the substitution of a chlorine atom at the 4-position. This structural modification makes it a valuable chiral building block and intermediate in organic synthesis, particularly for the development of pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and peptide research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially antibiotics and enzyme inhibitors.
• Peptide Modification: Used to incorporate chlorinated amino acid residues into synthetic peptides for structure-activity relationship (SAR) studies and to modulate peptide properties.
• Medicinal Chemistry Research: Acts as a building block for creating compound libraries in drug discovery programs targeting various diseases.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and enzyme mechanisms.
• Agrochemical Synthesis: Utilized as an intermediate in the development of advanced herbicides or plant growth regulators with specific chiral requirements.

Basic Information

Product Name	4-Chlorothreonine
CAS No.	132958-66-8
Molecular Formula	C4H8ClNO3
Molecular Weight	153.56 g/mol
Synonyms	(2S,3S)-2-Amino-3-chloro-4-hydroxybutanoic acid; (2S,3S)-4-Chlorothreonine; L-threo-4-Chlorothreonine; 4-Chloro-L-threonine; 3-Chloro-4-hydroxy-L-threonine; 4-Cl-Thr; Chlorothreonine
EINECS	Contact for details

Quality Control

Our 4-Chlorothreonine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.