Description

Enkephalin-Leu, Ala(2)-Ser(6)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, featuring specific amino acid substitutions. This compound is of significant interest in advanced biochemical and pharmacological research for studying opioid receptor interactions and signal transduction pathways. It serves as a critical tool for researchers and developers in the fields of neuroscience, peptide chemistry, and drug discovery, particularly for investigating pain modulation and developing novel therapeutic agents.

Application

• Neuroscience Research: As a reference standard and active agent in studies of the endogenous opioid system, receptor binding assays, and neuronal signaling.
• Pharmacological Studies: Used in vitro and in vivo to investigate analgesic pathways, tolerance development, and the physiological effects of enkephalin analogs.
• Biochemical Assay Development: Serves as a key component in the development and validation of high-throughput screening (HTS) assays for opioid receptor activity.
• Drug Discovery & Medicinal Chemistry: Acts as a lead compound or intermediate for the synthesis and optimization of novel peptide-based pharmaceuticals targeting pain management.
• Academic & Institutional Research: Provides a well-defined chemical tool for university labs and research institutes exploring neuropeptide function and metabolism.

Basic Information

Product Name	Enkephalin-Leu, Ala(2)-Ser(6)-
CAS No.	132930-82-6
Molecular Formula	C30H44N6O9
Molecular Weight	632.71 g/mol
Synonyms	[Leu5, Ala2, Ser6]-Enkephalin; H-Tyr-Gly-Ala-Phe-Leu-Ser-OH; Leu-Enkephalin, [Ala2,Ser6]-; L-Enkephalin, [Ala2, Ser6] derivative; Opioid peptide analog; (5-L-Leucine,2-L-alanine,6-L-serine)-enkephalin; Tyr-Gly-Ala-Phe-Leu-Ser
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, Ala(2)-Ser(6)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.